[et_pb_section fb_built=”1″ _builder_version=”4.25.2″ _module_preset=”default” background_color=”#dd0b00″ background_image=”https:\/\/ampac.occforum.com\/wp-content\/uploads\/2024\/07\/Untitled-design-3.png” background_blend=”overlay” custom_margin=”-8px||||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.2″ _module_preset=”default” text_font=”Oswald|300|||||||” text_text_color=”#FFFFFF” text_font_size=”50px” text_letter_spacing=”7px” text_line_height=”1.2em” text_orientation=”center” global_colors_info=”{}” content__hover_enabled=”off|desktop”]<\/p>\n
C\u00f3mo la Hiperglucemia<\/strong> promueve la Aterosclerosis:<\/strong> mecanismos moleculares<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.25.2″ _module_preset=”default” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.2″ _module_preset=”default” text_font=”|300|||||||” text_text_color=”#000000″ text_font_size=”17px” text_line_height=”1.8em” global_colors_info=”{}”]<\/p>\n Tanto la diabetes tipo I como la tipo II<\/strong> son factores de riesgo potentes e independientes para la enfermedad arterial coronaria (EAC), el accidente cerebrovascular y la enfermedad arterial perif\u00e9rica. La aterosclerosis es responsable de aproximadamente el 80% de todas las muertes entre los pacientes diab\u00e9ticos. La exposici\u00f3n prolongada a la hiperglucemia es ahora reconocida como un factor importante en la patog\u00e9nesis de la aterosclerosis en la diabetes. La hiperglucemia induce un gran n\u00famero de alteraciones a nivel celular en el tejido vascular que potencialmente aceleran el proceso ateroscler\u00f3tico. Estudios en animales y humanos han elucidado tres mecanismos principales que abarcan la mayor\u00eda de las alteraciones patol\u00f3gicas observadas en la vasculatura diab\u00e9tica: 1) La glicosilaci\u00f3n no enzim\u00e1tica de prote\u00ednas y l\u00edpidos que puede interferir con su funci\u00f3n normal alterando la conformaci\u00f3n molecular, modificando la actividad enzim\u00e1tica, reduciendo la capacidad degradativa e interfiriendo con el reconocimiento del receptor.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/1475-2840-1-1″ url_new_window=”on” button_text=”LEER M\u00c1S” button_alignment=”center” _builder_version=”4.25.2″ custom_button=”on” button_text_size=”20px” button_text_color=”#000000″ button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”5px” button_font=”Oswald|500||on|||||” button_use_icon=”off” custom_margin=”||” custom_padding=”15px||15px||true” box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#fa2a20″ locked=”off” global_colors_info=”{}” button_text_color__hover=”#000000″ button_border_width__hover=”2px” button_bg_color__hover=”#ffffff” box_shadow_vertical__hover=”8px” box_shadow_vertical__hover_enabled=”on” button_border_color__hover=”#ffffff”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" How hyperglycemia promotes atherosclerosis: molecular mechanisms<\/p>\n","protected":false},"author":1,"featured_media":1390,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"1080","footnotes":""},"categories":[11],"tags":[],"class_list":["post-1389","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aterosclerosis"],"_links":{"self":[{"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/posts\/1389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1389"}],"version-history":[{"count":5,"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/posts\/1389\/revisions"}],"predecessor-version":[{"id":1664,"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/posts\/1389\/revisions\/1664"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/media\/1390"}],"wp:attachment":[{"href":"https:\/\/miampac.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}