{"id":1383,"date":"2024-07-08T22:18:30","date_gmt":"2024-07-08T22:18:30","guid":{"rendered":"https:\/\/ampac.occforum.com\/?p=1383"},"modified":"2024-08-05T20:08:46","modified_gmt":"2024-08-05T20:08:46","slug":"hif-en-el-corazon","status":"publish","type":"post","link":"https:\/\/miampac.org\/?p=1383","title":{"rendered":"HIF en el Coraz\u00f3n:"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.25.2″ _module_preset=”default” background_color=”#dd0b00″ background_image=”https:\/\/ampac.occforum.com\/wp-content\/uploads\/2024\/07\/Untitled-design-3.png” background_blend=”overlay” custom_margin=”-8px||||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” theme_builder_area=”post_content” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.25.2″ _module_preset=”default” text_font=”Oswald|300|||||||” text_text_color=”#FFFFFF” text_font_size=”50px” text_letter_spacing=”7px” text_line_height=”1.2em” text_orientation=”center” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” sticky_enabled=”0″]

HIF <\/strong>en el Coraz\u00f3n:<\/strong> Desarrollo, Metabolismo, Isquemia y Aterosclerosis<\/strong><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.25.2″ _module_preset=”default” da_disable_devices=”off|off|off” global_colors_info=”{}” theme_builder_area=”post_content” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.25.2″ _module_preset=”default” text_font=”|300|||||||” text_text_color=”#000000″ text_font_size=”17px” text_line_height=”1.8em” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” sticky_enabled=”0″]

El coraz\u00f3n<\/strong> se forma temprano en el desarrollo y suministra sangre oxigenada al resto del embri\u00f3n. Despu\u00e9s del nacimiento, el coraz\u00f3n requiere kilogramos de ATP diariamente para mantener la contractilidad necesaria para la circulaci\u00f3n. El metabolismo card\u00edaco es omn\u00edvoro, utilizando m\u00faltiples sustratos y v\u00edas metab\u00f3licas para producir esta energ\u00eda. El desarrollo card\u00edaco, la afinaci\u00f3n metab\u00f3lica y la respuesta a la isquemia est\u00e1n regulados en parte por los factores inducibles por hipoxia (HIF), componentes centrales de las v\u00edas de se\u00f1alizaci\u00f3n esenciales que responden a la hipoxia. Aqu\u00ed revisamos las acciones de HIF1, HIF2 y HIF3 en el coraz\u00f3n, desde sus roles en el desarrollo y el metabolismo hasta su actividad en la regeneraci\u00f3n y las estrategias de preacondicionamiento. Tambi\u00e9n discutimos trabajos recientes sobre el papel de los HIF en la aterosclerosis, la causa precipitante de la isquemia mioc\u00e1rdica y la principal causa de muerte en el mundo desarrollado.<\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_url=”https:\/\/www.jci.org\/articles\/view\/137557″ url_new_window=”on” button_text=”LEER M\u00c1S” button_alignment=”center” _builder_version=”4.25.2″ custom_button=”on” button_text_size=”20px” button_text_color=”#000000″ button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”5px” button_font=”Oswald|500||on|||||” button_use_icon=”off” custom_margin=”||” custom_padding=”15px||15px||true” hover_enabled=”0″ box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#fa2a20″ locked=”off” global_colors_info=”{}” button_text_color__hover=”#000000″ button_border_width__hover=”2px” button_bg_color__hover=”#ffffff” box_shadow_vertical__hover=”8px” box_shadow_vertical__hover_enabled=”on” button_border_color__hover=”#ffffff” theme_builder_area=”post_content” sticky_enabled=”0″][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

HIF en el Coraz\u00f3n: Desarrollo, Metabolismo, Isquemia y AterosclerosisEl coraz\u00f3n se forma temprano en el desarrollo y suministra sangre oxigenada al resto del embri\u00f3n. Despu\u00e9s del nacimiento, el coraz\u00f3n requiere kilogramos de ATP diariamente para mantener la contractilidad necesaria para la circulaci\u00f3n. El metabolismo card\u00edaco es omn\u00edvoro, utilizando m\u00faltiples sustratos y v\u00edas metab\u00f3licas para producir […]<\/p>\n","protected":false},"author":1,"featured_media":1384,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"1080","footnotes":""},"categories":[11],"tags":[],"class_list":["post-1383","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aterosclerosis"],"_links":{"self":[{"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/posts\/1383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1383"}],"version-history":[{"count":4,"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/posts\/1383\/revisions"}],"predecessor-version":[{"id":1653,"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/posts\/1383\/revisions\/1653"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=\/wp\/v2\/media\/1384"}],"wp:attachment":[{"href":"https:\/\/miampac.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/miampac.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}